Hyaluronic acid decreases as we age

At young age the human body is very rich with hyaluronic acid, the reason young people have firm well hydrated skin and prompted healing process. Our skin is exposed to environmental pollutants and the sun's ultraviolet rays and our cells gradually lose the ability to produce hyaluronic acid. Studies have shown that older skin typically has much lower levels of hyaluronic acid than younger skin. As we age, our skin tissue becomes dehydrated and the collagen and elastin fibers lose their structure, resulting in a loss of skin volume and the formation of the facial wrinkles and folds that are common characteristics of aged skin. Low hyaluronic acid levels in the skin makes it more susceptible to wrinkles, dehydration and infection.

The decrease of hyaluronic acid starts at around the age of 20, but becomes apparent when people get into their 30s and 40s. Loss of hyaluronic acid has a negative impact on the fibroblasts of the skin, leading to even less collagen being made, which also cause the skin to become far less elastic. An enzyme action in the skin called hyaluronidase breaks down hyaluronic acid, and this is why we need to replenish to maintain a smooth and healthy skin.

Hyaluronic acid in anti-aging

Many cosmetic and medical companies have considered the important role of this molecule in fighting aging process and introduced it into their technology. This technology is applied for the most popular injectable fillers, oral supplements and cosmetic creams.

Topical applied hyaluronic acid

Topical application faces the challenges that the hyaluronic acid molecules have to be extremely small to be able to penetrate the epidermis and small molecule hyaluronic acid is less effective.

Oral hyaluronic acid supplements

The side effects of oral doses hyaluronic acid side effects can be much more severe than injections or topical use. It is recommended only to use the oral version under supervision of a doctor. Side effects may include digestive problems, nausea, vomiting, fatigue, shortness of breath, lethargy, headache, and changes in energy or mood. These are the most severe side effects associated with taking oral hylaluronic acid. The exact number of people who experience these effects is unknown because oral supplements of this kind have not been fully tested or studied. If hyaluronic acid side effects become severe or prolonged, a doctor should be notified and the supplements should be discontinued. There is no research to indicate that oral regimens are effective, and long-term safety has not yet been established.

Hyaluronic acid filler injections are safe and effective

All doctors will agree that injections with hyaluronic acid are most effective to replenish the skin, fill in fine lines, folds and wrinkles. Injectable soft-tissue fillers rarely lead to serious complications. The complication rate is lowest with hyaluronic acid fillers (0.2%) and therefore can be seen as extremely safe. The results last 6 months or longer, depending on the product which is used.

Anne-Marie van Geloven